Not surprisingly, the opener won't work unless it is connected to a functional power supply. It's easy to accidentally unplug the unit to make way for another garden appliance; make sure the power cord is still connected directly to an outlet – no extension cords – and confirm the power is turned on.
The spring regulating the speed the garage door opens and closes could have come loose or snapped. Inspect the spring either side of the door, ensuring it is still in place. Without the spring in place the weight of the door becomes too much for the unit to lift.
Subzero temperatures freeze the rubber strip on the underside of the door to the ground if the area isn't treated with salt, sand or antifreeze. Thaw out the area and try opening the door again. The upward force required to break the ice is often beyond the limits of the motor.
Repeated use of the LiftMaster 41A5021 could cause the motor to overheat. Stop all use and wait 15 minutes for the overload protection device in the motor to reset itself. The opener should operate normally once a safe operating temperature is achieved. In the future, avoid opening and closing the door in quick succession.
Make sure to release all of the locks securing the garage door before operating the opener. Some garage doors have a separate key lock incorporated into the exterior handle to provide an additional layer of security over the electronic entry codes used by the opener. As a safeguard against damage, LiftMaster openers only apply a certain amount of force before abandoning an attempt to open the garage.