Remove all package materials. Look for plastic tabs that may be holding vents in place.
Install or plug in the air cleaner. Honeywell air cleaners come in a variety of sizes. Larger units, such as the F500 Whole House/Light Commercial HEPA Filtration System, are connected to the return air duct of the house's existing heating system. The units are designed to clean the air before the air goes through the furnace and is forced through the ducts into the house. Smaller units fit on a countertop or sit in an out-of-the way corner. Smaller units typically are only efficient to clean the air in one or two rooms. It recycles the air in the room through the filter to clean. If the unit is expected to purify the air from more than one room, place the unit in a central area, not in a corner where the air flow may be constricted.
Follow the Honeywell manual that came with your unit to install the filters. Turn the unit on. You may notice a difference in the air quality immediately or it may take time, depending on the area the unit is cleaning.