Put newspaper or plastic sheeting down on a work surface. Work outdoors or in a location with adequate ventilation.
Remove the Plexiglas face from your frame. Check to see if there is a protective film on the Plexiglas and peel it off if you find one.
Apply a small amount of mineral spirits to a rag. Wipe the Plexiglas to remove any dirt or grease. Go over the surface with a clean, lint-free rag.
Place the Plexiglas on the work surface with the back of the Plexiglas exposed. Shake the can of spray paint thoroughly. Spray the paint using a sweeping motion. Apply light, even coats of spray paint until you achieve the desired opacity.
Let the spray paint dry for at least an hour. Reassemble the frame with the sprayed Plexiglas surface facing inward. Place the backing that comes with the frame against the painted surface. Be careful not to scratch the spray paint.