Prepare the soil before planting. Besides the seed quality, soil quality is the most important asset under your control. Test your soil for deficiencies, and work a balanced vegetable fertilizer 6 inches into the garden site according to the fertilizer's directions.
Plant your seeds or pumpkin plants only after all threat of frost is over. If cold weather threatens your seedlings, protect them with a row cover. When planting, give each vine at least 150 square feet of space.
As the giant pumpkin plant grows, top-dress the soil with compost every two weeks. Use a soaker hose or drip irrigation system to water the pumpkin plant, as overhead watering encourages powdery mildew. Water early in the day to prevent diseases.
Treat pest or disease problems immediately. Squash bugs may decimate a young pumpkin plant within days, and fungal diseases like powdery mildew destroy foliage, starving your plant. Choose the appropriate pesticide and follow application directions.
Harvest your pumpkins when the stem is dry and woody, the rind hardens and the skin has a bright color. Use a sharp knife to cut the stem at least 2 inches from the pumpkin.