Weed and clear the garden bed of all fallen plant debris throughout the gardening season. Hornworm pupae develop inside the soil and the litter left on top. Removal of the debris and litter minimizes the hornworm population.
Till the soil after pulling the tomato plants in fall. Tilling destroys any overwintering hornworm pupae and caterpillars in the soil.
Rotate your crops yearly to prevent hornworms that did overwinter successfully from finding your tomato plants. Avoid planting tomatoes, potatoes, peppers or eggplants in the same bed or two years in a row. Hornworms feed on all these plant varieties.
Inspect the plants daily for hornworms if defoliation occurs. Pick the caterpillars off the plants and submerge them in soapy water to kill them.