Wear work gloves to protect your hands from possible irritation.
Grasp the base of the pokeweed as close to ground level as possible. If roots are left behind, new pokeweed plants will sprout.
Pull small infestations of pokeweed out of the ground and immediately dispose of the weeds in a sealed garbage bag.
Monitor the area regularly and pull any pokeweed plants that emerge.
Wear safety glasses and latex or rubber gloves.
Pour 1/2 gallon of water into a large bucket. Add 1 to 2 tablespoons of an herbicide that lists Dimethylamine salt of 2,4-D-Dichlorophenoxyacetic acid (2,4-D) as its active ingredient per the package instructions. Mix the water and herbicide thoroughly with a wood stirring stick.
Add 1 teaspoon of a non-ionic surfactant to the diluted herbicide. Stir the solution with the wood stirring stick for several seconds. The non-ionic surfactant will help provide better coverage of the herbicide, increasing its effectiveness.
Transfer the herbicide solution to a garden sprayer. Spray pokeweed leaves with the herbicide solution thoroughly until the plant is moist. Protect desirable plants growing near the pokeweed by covering them with a piece of cardboard while spraying the pokeweeds.
Monitor the area and spray newly emerged pokeweeds with the herbicide solution as you find them.