Put on a long-sleeved shirt, long pants, safety glasses and disposable gloves to protect skin and eyes from splashing chemicals.
Dig the soil with a shovel from around big roots on bushes or plants to expose the roots. Scoop out soil with your hands to remove it and make the entire root system visible.
Insert a 1-inch drill bit into a cordless drill. Drill holes in the roots about 1/2 inch deep and a few inches apart.
Shake a bottle of 41 percent glyphosate stump killer to mix the ingredients. Remove the lid and pour the herbicide onto one side of a paintbrush. Tilt the brush to let the herbicide drip downward and onto the roots. Paint the entire surface of the roots with glyphosate.
Hold the bottle of herbicide close to the holes in the roots. Pour the stump killer into each hole and fill them to the top.
Remove the gloves, dispose of them and the paintbrush into the garbage.
Pull the roots out by hand after they die and have started to decay.