Wait until the cotton plants reach 20 to 30 inches high to apply the first application of mepiquat chloride to them.
Don the appropriate clothing and safety gear prior to application, which includes long sleeves, pants, chemical resistant gloves, safety glasses and a mask.
Fill an irrigation system or large-sized liquid fertilizer sprayer with 2 to 4 oz. of liquid mepiquat chloride for every acre of cotton that you are spraying. Then add 2 gallons of water for every acre of land. If you live in the state of California, you must use 5 gallons of water for every acre of cotton.
Spray the cotton plants with the solution until all surfaces of the plant including stems and leaves are saturated. Keep the sprayers no more than 10 feet above the cotton at all times.
Repeat the application process with the same amount of mepiquat chloride an additional four or five times during the growing season. Space each application at least 7 to 14 days apart.