The size of a handmade centerpiece should coordinate with the size of the table so that the accent will not appear too overwhelming. A coffee table centerpiece such as a small vase filled with tulips and baby's breath you've grown in your garden is ideal for a formal living room; a centerpiece shaped like a cornucopia and filled with craft supplies like synthetic dried corn cobs and pine cones makes a lovely Thanksgiving or fall season decoration.
Your handmade centerpiece can also serve special significance in the room where it is displayed. For instance, bind a group of yellow roses together with satin ribbon and display the centerpiece in the foyer of your home; yellow is the color of friendship, and will signify that your loved ones are welcomed in your home. Or, use a wooden or glass bowl filled with dried fruits and homemade candy in your kitchen to create an edible and colorful centerpiece.
Creating centerpieces especially fitting for an occasion will make your venue visually appealing. For instance, if you're decorating for a baby shower, fill glass baby bottles with white flowers to represent innocence or new life, and tie a ribbon around the bottle to denote the gender of the baby; filling the bottles with pink or blue jelly beans is a great idea as well.