Clear the wood of any obstacles. For example, if you are working on a wood floor, remove the furniture and carpets from the room. Cabinetry and other furniture should be stripped of all hardware and broken down into as many pieces as possible so you have easy access to the visible surfaces.
Wipe or sweep away any dirt, dust or other abrasive material that might get caught up in the sander and gouge the floor. Sand the knotty pine surface down to bare wood with medium-grade sandpaper. If working on a floor or other broad, flat surface, use an orbital sander. Otherwise, sand by hand with a sanding block or sanding sponge.
Wipe the knotty pine to get rid of the excess dust. Sand it smooth, working in the direction the grain, with fine-grade sandpaper to give it a smooth surface that's ready to absorb stain.
Apply stain with a tool that is appropriate for the surface you're working with. When staining wood surfaces, you have the option to use paint rollers, paint sprayers, paintbrushes and cloths, but you should always use the tool that will get the stain on the surface cleanly and quickly. For example, broad, flat surfaces, such as floors, walls and tabletops, should be tackled with a roller or sprayer. Smaller objects should be stained with a paintbrush or cloth. No matter which tool or surface you are working with, always apply stain with the grain.
Let the stain soak into the pine for about 30 seconds, and then wipe the wood down with a clean cloth to absorb the excess stain, which can pool on horizontal surfaces or run on vertical ones. Allow the stain to dry.
Apply a protective sealer, such as varnish, polyurethane or lacquer. Instructions for applying wood sealers vary by product and manufacturer so always read the label thoroughly before using them.