Slip the mattress cover over the futon mattress. Close the zipper to seal off bedbugs from getting into your mattress. Mattress covers use a tightly woven fabric that restricts bedbugs from getting into the mattress and locks in bedbugs that may have made their way into the futon already. Bedbugs, which require a host to survive, will die within two days after being cut off.
Vacuum your home's floors, focusing on cracks and crevices where bedbugs tend to hide. Remove the vacuum cleaner bag outside of your home and place it in a sealable plastic bag to prevent the bedbugs from spreading.
Wash and dry your clothes and bed linens on a high heat setting. A heat setting above 120 degrees Fahrenheit for 20 minutes kills bedbugs and their eggs, according to the Mayo Clinic.