Deflate the bed as much as you can so that no air is exiting the hole. This allows the epoxy sealant to dry without being displaced by exiting air.
Prep the hole and its surrounding area. Clean the area using rubbing alcohol applied to a cotton swab. Cleaning the area allows the epoxy to bond to the mattress as opposed to bonding to a layer of filth covering the surface.
Apply enough epoxy sealant to cover the hole and wipe off any excess, then cover it with a patch. Allow the patch to dry according to the directions on the patch kit. Fill the bed with air, feel around the patch for air and listen for a leak.