Determine if you have an air mattress that self inflates with an adjustable compressor or inflates with a manual pump. If it is self inflating, skip to Step 3, otherwise proceed to Step 2.
Blow up the air mattress with the pump to the desired firmness. Lay on the mattress in your normal sleeping position. If you still feel pressure points, let out some of the air and try again until the pressure points are less noticeable.
Adjust the firmness or pressure control on the compressor to a lower firmness. Try out the firmness by lying on the mattress. Readjust as needed.
Try sleeping in different positions to further reduce pressure points.