Take the crib apart completely. While you can paint the crib while it's still together, you risk missing spots or leaving visible paint drips.
Sand the crib with a piece of fine-grit sandpaper. Ensure you get every crevice to help the paint adhere to the surface.
Apply a coat of paint evenly to the crib. Allow the paint to dry according to manufacturer's directions.
Apply a second coat of paint if necessary before adding decorative touches. Allow the second coat or decorative touches to dry completely.
Paint on a coat of baby-safe clear coat over the paint. The clear coat helps protect the paint job.
Allow the clear coat to dry according to directions on the bottle. Put the crib back together, and place it in the nursery.