Shut down, unplug and remove your computer and peripherals, as well as all of the other items on your computer desk.
Clean the desk by wiping it with a 50/50 mixture of distilled white vinegar and water. Allow the desk to dry completely.
Measure and cut the wrapping paper to cover your desk and trim. Try to make as few cuts as necessary and cut the desk top pieces long and wide enough to cover the front and side edging.
Using a clean paintbrush, cover your desk with a thin layer of white glue, and allow it to dry (approximately 2 hours; you will know the glue is dry when it is completely clear).
Apply a thin layer of decoupage medium to the desk's surface with another clean brush, then carefully press the wrapping paper onto the desk. While the medium is wet, you can smooth the paper with the edge of a ruler or a Popsicle stick.
Let the medium dry for 15 to 20 minutes.
Using a clean paintbrush, apply four coats of decoupage medium to the paper, letting each coat dry for approximately 15 minutes before going onto the next. When the decoupage medium goes from white to clear, it is dry.