Grind down the parts of the wheel that make contact with the ground using sandpaper if they are uneven and cause the wheelchair to lean. A uniform thickness will provide for easier mobility.
Rub the wheel surface and all other parts of the wheel with a wet towel to clean off excess dirt, debris and other grime. According to the Wheelchair Site, dirt, grime and dust can compromise the proper movement and damage parts.
Tighten bolts and nuts that attach the wheel to the rest of the wheelchair, using a wrench that fits the specific bolts and nuts. Loose wheels will not make contact with the ground in the way they are designed.
Pluck out shards of debris that may be stuck in the wheels or other moving parts, using pliers. The WisTech Assistive Technology Program recommends removing hair, string and any other items that interfere with proper rolling.
Lubricate moving parts on the wheel using commercial lubricating fluid. Any type of chain, ball bearing or spot where a part of the wheelchair flexes should be lubricated occasionally to prevent rusting. Many commercial lubricating fluids will come with a straw applicator or spray top to apply the product.