In order for a panel board surface to support the heavy weight of tile and mortar, the panel board must be part of the underlying wall's structure. Locate the studs in the wall behind the panel board. Mark their locations with a pencil. Screw 2 1/2-inch galvanized screws through the panel board and into each stud. Space these screws every 3 to 6 inches. The long length of the screws gives the panel board surface extra stability against the pull of the tiles' collective weight. The close spacing leaves almost no room for the panel board wall to pull away from the wall.
Prior to applying the mastic to the panel board surface that allows the tile to stick in place, sand the panel board. Typically, the shiny finish on the panel board makes it difficult for anything to stick or bind to it. Roughing up the surface gives the mastic a better base to bind.
Use a layer of cement board to cover the panel board before tiling. The cement board adds strength and durability. It also lends a level of moisture control to the backsplash's foundation. Even though tiles cover a backsplash area, moisture may find its way behind the tiles in order to soak into the underlying wall. The addition of the water-resistant cement board minimizes moisture damage behind the wall.
Whether tiling directly on the panel board or on the overlying cement board, use a generous amount of tile adhesion. Even coverage ensures a good bond between the tiles and the wall. The binding mastic and mortar between the tiles add an extra layer of durability to the wall for the long term.