Treat the wasp nest above the ceiling with wasp spray before attempting to replace the ceiling. Spray the nest in the late evening, if possible, when most of the wasps remain in the nest, and stand at the distance that the manufacturer recommends from the wasp nest, generally at least 10 feet to avoid getting stung.
Watch the spot where the wasps have been entering the house throughout the following day to ensure that the wasps have gone. If you see any wasps, repeat the spraying process again after three days. Watch for wasps the day after, and repeat spraying every three days until you see no sign of the wasps.
Remove the section of the ceiling damaged due to the wasps. Cut away sections of drywall with a utility knife and pry the drywall from the ceiling with a hammer. Break up plaster ceilings with a chisel and hammer.
Cut a piece of drywall to the size of the piece of the ceiling that you removed, and secure the drywall in place with drywall screws, sinking them 1/8-inch into the surface. Fill in the cracks and the dips above the screws with joint compound. Mix a batch of plaster according to the directions and spread three layers of plaster over the part of plaster ceiling from which the surface has been removed.
Cover the area of the ceiling from which you removed the drywall or plaster with a paint color or ceiling covering that matches the rest of the ceiling. Fill in the hole through which the wasps entered the space above the ceiling with filler or foam.